Islet Biology and Metabolism Lab

2023

The organic nitrate NDBP promotes cardiometabolic protection in type 1 diabetic mice. Fernandes-Costa, Francineide ; Gomes Da Silva, Rayanelle Tissiane ; Flôr, Atalia Ferreira De Lima ; Cláudia R. Brandão, Maria ; Athayde-Filho, Petrônio F. ; França-Falcão, Maria Do Socorro ; De Andrade Braga, Valdir ; Jorge Dos Santos, Gustavo ; Carlstrom, Mattias ; Cruz, Josiane De Campos. Journal of Functional Foods, v. 104, p. 105526, 2023.

2022

Hepatocyte Nuclear Factor 4-α (HNF4α) controls the insulin resistance-induced pancreatic β-cell mass expansion. Barth, Robson ; Ruoso, Carolina ; Ferreira, Sandra Mara ; De Ramos, Francieli Caroline ; Lima, Fernanda Barbosa ; Boschero, Antônio Carlos ; Santos, Gustavo Jorge Dos . LIFE SCIENCES, v. 289, p. 120213, 2022.

The Role of GABA in Islet Function. Hang, D. W. ; Ferreira, S. M. ; Santos, G. J. ; Phelps, E. A. Frontiers in Endocrinology, v. 1, p. e, 2022.

Paternal Exercise Improves the Metabolic Health of Offspring via Epigenetic Modulation of the Germline. Costa-Júnior, José Maria ; Ferreira, Sandra Mara ; Kurauti, Mirian Ayumi ; Bernstein, Diana L. ; Ruano, Elena G. ; Kameswaran, Vasumathi ; Schug, Jonathan ; Freitas-Dias, Ricardo ; Zoppi, Claudio C. ; Boschero, A. C. ; Oliveira, Camila A. M. De ; Santos, G. J. ; Carneiro, Everardo M. ; Kaestner, Klaus H. . INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, p. 1, 2022.

Pep19 Has a Positive Effect on Insulin Sensitivity and Ameliorates Both Hepatic and Adipose Tissue Phenotype of Diet-Induced Obese Mice. Silvério, Renata ; Barth, Robson ; Heimann, Andrea S. ; Reckziegel, Patrícia ; Dos Santos, Gustavo J. ; Romero-Zerbo, Silvana Y. ; Bermúdez-Silva, Francisco J. ; Rafacho, Alex ; Ferro, Emer S. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, p. 4082, 2022.

Offspring from trained male mice inherit improved muscle mitochondrial function through PPAR co-repressor modulation. Freitas-Dias, Ricardo ; Lima, Tanes I. ; Costa-Junior, Jose Maria ; Gonçalves, Luciana M. ; Araujo, Hygor N. ; Paula, Flavia M.M. ; Santos, Gustavo J. ; Branco, Renato Chaves Souto ; Ou, Kristy ; Kaestner, Klaus H. ; Silveira, Leonardo R. ; Oliveira, Camila A.M. ; Boschero, Antonio C. ; Zoppi, Claudio C. ; Carneiro, Everardo M. LIFE SCIENCES, v. 291, p. 120239, 2022.

Antidepressant-like activity of gestational administration of vitamin D is suppressed by prenatal overexposure to dexamethasone in female Wistar rats. Gregorio, Tamires ; Lorenzon, Flaviano ; Niebisch, Fernanda ; Stolte, Rafaela Carla Kachel ; Rafacho, Alex ; Jorge Dos Santos, Gustavo ; De Oliveira, Cilene Lino ; Lima, Fernanda Barbosa . PHYSIOLOGY & BEHAVIOR, v. 1, p. 113765, 2022.

Metformin improves neurobehavioral impairments of streptozotocin-treated and western diet-fed mice: Beyond glucose-lowering effects. Delanogare, Eslen ; Bullich, Sebastien ; Dos Santos Barbosa, Lucas Antônio ; De Medeiros Barros, Wellinghton ; Braga, Sara Pereira ; Kraus, Scheila Iria ; Kasprowicz, Júlia Nahir ; Dos Santos, Gustavo Jorge ; Guiard, Bruno Pierre ; Moreira, Eduardo Luiz Gasnhar. FUNDAMENTAL & CLINICAL PHARMACOLOGY, v. 1, p. 10.1111/fcp.128, 2022.

2021

Maternal vitamin D administration attenuates metabolic disturbances induced by prenatal exposure to dexamethasone in a sex-dependent manner. Lorenzon, Flaviano ; Gregorio, Tamires ; Niebisch, Fernanda ; Stolte, Rafaela C.K. ; Dos Santos, Gustavo J. ; Rafacho, Alex ; Lima, Fernanda B. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, v. 1, p. 105941, 2021.

Excess of glucocorticoids during late gestation impairs the recovery of offspring?s β-cell function after a postnatal injury. Santos, Cristiane ; Rafacho, Alex ; Ferreira, Sandra Mara; Vettorazzi, Jean Franciesco ; Reis Araújo, Thiago ; Mateus Gonçalves, Luciana ; Ruhrmann, Sabrina ; Bacos, Karl ; Ling, Charlotte ; Boschero, Antônio Carlos ; Jorge Dos Santos, Gustavo . FASEB JOURNAL, v. 35, p. e21828, 2021.

Reduced insulin sensitivity and increased β/α cell mass is associated with reduced hepatic insulin-degrading enzyme activity in pregnant rats. Taschetto, Ana P.D. ; Zimath, Priscila L. ; Silvério, Renata ; Dos Santos, Cristiane ; Boschero, Antonio C. ; Dos Santos, Gustavo J. ; Rafacho, Alex . LIFE SCIENCES, v. 1, p. 119509, 2021.

2020

FERREIRA, SANDRA M. ; COSTA-JÚNIOR, JOSÉ M. ; KURAUTI, MIRIAN A. ; LEITE, NAYARA C. ; ORTIS, FERNANDA ; Rezende, Luiz F. ; BARBOSA, HELENA C. ; Boschero, Antonio C. ; Santos, Gustavo J. . ARHGAP21 Acts as an Inhibitor of the Glucose-Stimulated Insulin Secretion Process. Frontiers in Endocrinology, v. 11, p. 2020, 2020.

2019

Leucine increases muscle mitochondrial respiration and attenuates glucose intolerance in diet-induced obesity in Swiss mice. Brunetta, Henver Simionato ; De Paula, Gabriela Cristina ; Fritzen, Matheus ; Cecchini, Manuela Sozo ; Santos, Gustavo Jorge Dos ; Nazari, Evelise Maria ; Rafacho, Alex ; De Bem, Andreza Fabro ; Nunes, Everson Araújo. Journal of Functional Foods, v. 62, p. 103544, 2019.

2018

Decrement in resting and insulin-stimulated soleus muscle mitochondrial respiration is an early event in diet-induced obesity in mice. Brunetta, Henver Simionato ; De Paula, Gabriela Cristina ; De Oliveira, Jade ; Martins, Eduarda Lopes ; Dos Santos, Gustavo Jorge ; Filho, Antonio Galina ; Rafacho, Alex ; De Bem, Andreza Fabro ; Nunes, Everson Araújo. EXPERIMENTAL PHYSIOLOGY, v. 01, p. 01, 2018.

2017

Interleukin-6 increases the expression and activity of insulin-degrading enzyme. Kurauti, Mirian A.; Costa-Júnior, José M. ; Ferreira, Sandra M. ; Santos, Gustavo J. ; Sponton, Carlos H. G. ; Carneiro, Everardo M. ; Telles, Guilherme D. ; Chacon-Mikahil, Mara P. T. ; Cavaglieri, Cláudia R. ; Rezende, Luiz F. ; Boschero, Antonio C. Scientific Reports, v. 7, p. 46750, 2017.

2016

Acute exercise restores insulin clearance in diet-induced obese mice. Kurauti, Mirian Ayumi ; Costa-Júnior, José Maria ; Ferreira, Sandra Mara ; Santos, Gustavo Jorge ; Protzek, André Otávio Peres ; Nardelli, Tarlliza Romanna ; Rezende, Luiz Fernando ; Boschero, Antonio Carlos. Journal of Endocrinology, v. 3, p. JOE-15-0483, 2016.

Acute Exercise Improves Insulin Clearance and Increases the Expression of Insulin-Degrading Enzyme in the Liver and Skeletal Muscle of Swiss Mice. Kurauti, Mirian A. ; Freitas-Dias, Ricardo ; Ferreira, Sandra M. ; Vettorazzi, Jean F. ; Nardelli, Tarlliza R. ; Araujo, Hygor N. ; Santos, G. J. ; Carneiro, Everardo M. ; Boschero, A. C. ; Rezende, Luiz F. ; Costa-Júnior, José M.. Plos One, v. 11, p.e0160239, 2016.

 

2015

ARHGAP21 prevents abnormal insulin release through actin rearrangement in pancreatic islets from neonatal mice. Ferreira, Sandra Mara ; Santos, Gustavo Jorge ; Rezende, Luiz F. ; Gonçalves, Luciana Mateus ; Santos-Silva, Junia Carolina ; Bigarella, Carolina Louzão ; Carneiro, Everardo Magalhães ; Saad, Sara Teresinha Ollala ; Boschero, Antonio Carlos ; Barbosa-Sampaio, Helena Cristina. Life Sciences (1973), v. pii, p. S0024, 2015.

Endurance Training Inhibits Insulin Clearance and IDE Expression in Swiss Mice. Costa-Junior, J. M. ; Ferreira, S. M. ; Protzek, A. O. P. ; Santos, G. J. ; Capelli, A.P. ; Silveira Lr ; Zoppi C ; Boschero, A. C. ; Carneiro, E. M. ; Rezende, L.F. Plos One, v. 3, p. e0118809, 2015.

2014

Metabolic Memory of ß-Cells Controls Insulin Secretion and is Mediated by CaMKII. Santos, Gustavo Jorge Dos; Ferreira, Sandra Mara ; Ortis, Fernanda ; Rezende, Luiz Fernando ; Li, Chengyang ; Naji, Ali ; Carneiro, Everardo Magalhães ; Kaestner, Klaus H. ; Boschero, Antonio Carlos. Molecular Metabolism, v. 4, p. 10.1016/j.molme, 2014.

Augmented β -Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir- β /AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling. Protzek, André O. P. ; Costa-Júnior, José M. ; Rezende, Luiz F. ; Santos, Gustavo J. ; Araújo, Tiago Gomes ; Vettorazzi, Jean F. ; Ortis, Fernanda ; Carneiro, Everardo M. ; Rafacho, Alex ; Boschero, Antonio C. International Journal of Endocrinology, v. 2014, p. 1-14, 2014.

2013

Cafeteria diet inhibits insulin clearance by reduced IDE expression and mRNA splicing. Brandimarti, P. ; Costa-Junior, J. M. ; Ferreira, S. M. ; Santos, G. J. ; Protzek, A. O. P. ; Carneiro, E. M. ; Boschero, A. C. ; Rezende, L. F.. Journal of Endocrinology, v. 219, p. 173-182, 2013.